Manchester United come into this game on the back of a 3-0 victory over Derby County in the FA Cup.
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They came up against an old friend in Wayne Rooney during that game, but it is an old foe they are coming up against this time around in Manchester City.
Not only is local pride at stake for the victor, but if Ole Gunnar Solskjaer’s side overcome City, they could potentially move up into the top four.
They will be desperate for this to happen, and FFC has predicted the XI that may be utilised to make sure that is the case, including five changes from the win against Derby.
David De Gea comes back in goal, despite making a mistake during the 1-1 draw against Everton, with Solskjaer sticking by him.
There is no change at right-back, as Aaron Wan-Bissaka is a doubt for the game, as reported by the club’s official website.
While Harry Maguire is also a doubt, Solskjaer did hint that he will play his captain if possible, so it is likely all will be done to get him into their team, with Luke Shaw and Victor Lindelof making up the rest of the backline.
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Solskjaer could revert back to a midfield diamond, with Nemanja Matic coming in to fulfil the holding role, Fred and Scott McTominay playing centrally and Bruno Fernandes playing in attacking midfield.
There will be plenty of excitement about seeing Fernandes against United’s city rivals, as he already has three goals and two assists from six starts and a substitute appearance across the Premier League, Europa League and FA Cup.
Daniel James is another doubt for the game, so Solskjaer may opt to leave him out. This will see him turn to Mason Greenwood to line up alongside Anthony Martial as the main strikers, though Odion Ighalo will also be in with a shout after scoring a brace on Thursday night.
Meanwhile, Jesse Lingard dedicated a post to Wayne Rooney after the FA Cup win.
